• UC Tools:
• Blackboard
• OneStop
• Libraries
• UConnect
• UC Mail
• UCFileSpace

Assistant Professor
Chemistry - Tenure-Track Faculty
1505A Crosley Tower
513-556-3049
george.stan@uc.edu

Research Support

(PI) Scientist Development Grant, American Heart Association. (0730167N); $259,992. Funded 01/01/2007 to 12/31/2010.

Peer Reviewed Publications

G. Stan, D. Thirumalai, G. H. Lorimer and B. R. Brooks. "Coupling between allosterictransitions in a single ring of GroEL and assisted folding of a substrate protein". Proc. Natl. Acad. Sci (2007), 104, 8803-8808.

G. Stan, B. R. Brooks, G. Lorimer and D. Thirumalai. "Residues in substrate proteinsthat interact with GroEL in the capture process are buried in the native state". Proc. Natl. Acad. Sci. (2006), 103, 4433-4438.

G. Stan, B. R. Brooks and D. Thirumalai. "Probing the “annealing” mechanism of GroELminichaperone using molecular dynamics simulations". J. Mol. Biol. (2005), 350, 817-829.

G. Stan, B. R. Brooks, G. H. Lorimer and D. Thirumalai. "Identifying natural substratesfor chaperonins using a sequence-based approach". Protein Science (2005), 14, 193-201.

G. Stan, D. Thirumalai, G. H. Lorimer and B. R. Brooks. "Annealing Function of GroEL:Structural and Bioinformatic analysis". Biophys. Chem. (2003), 100, 453-467.

E. P. O'Brien, G. Stan, D. Thirumalai, and B. R. Brooks. "Factors Governing Helix Formation in Peptides Confined to Carbon Nanotubes". Nano Lett. (2008), 8, 3702-3708.

Invited Presentations

(06-2007). Computational models of chaperonin-mediated protein folding. Albany conversations, SUNY at Albany.

(04/06/2007). Biological nanomachines at work: chaperonin-mediated protein folding. Mathematics Department, University of Cincinnati.

(03/07/2007). Secrets of biomolecular systems revealed by computer simulations: biological nanomachines for protein folding assistance. Department of Chemistry, Roosevelt University.

(12/15/2006). Biological nanomachines at work: chaperonin-mediated protein folding. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center.

(04/10/2006). Biological nanomachines at work: chaperonin-mediated protein folding. Biophysics Seminar, University of Maryland.

(02/14/2006). Biological nanomachines at work: chaperonin-mediated protein folding. Biology Department, George Washington University.

(01/26/2006). Escaping the traps: protein folding assistance by the chaperonin biological nanomachine. Department of Physics, Northeastern University.

(01/19/2006). Escaping the traps: protein folding assistance by the chaperonin biological nanomachine. Department of Chemistry, Temple University.

(01/12/2006). Biological Nanomachines at Work: Chaperonin-Mediated Protein Folding. Department of Physiology and Biophysics, Albert Einstein College of Medicine.

(12/05/2005). Biological Nanomachines at Work: Chaperonin-Mediated Protein Folding. Department of Chemistry, University of Cincinnati.

(11/30/2005). Protein Folding with a Little Help: Annealing Action of the Chaperonin Biological Nanomachine. Department of Physics, Oakland University.

(11/21/2005). GroEL substrate proteins: A bio-informatic approach. Chaperonin symposium, University of Maryland, College Park, MD.

(11/09/2005). Chaperonin molecules - biological nanomachines for protein folding. Department of Chemistry, University of Massachusetts, Lowell.

(10/24/2005). Chaperonin-mediated protein folding. Lenfant Fellowship Award Lecture, NHLBI, NIH, Bethesda, Maryland.

(03/28/2005). The spectacular works of a biological nanomachine for simulated annealing: chaperonin-assisted protein folding. Department of Physics, Clemson University.

(03/10/2004). Computational studies of chaperonin-mediated protein folding. Center for Neutron Research, NIST, Gaithersburg, Maryland.

Poster Presentations

(06-2007). Computational models of chaperonin-mediated protein folding. Albany conversations, SUNY at Albany.

G. Stan, B. R. Brooks, D. Thirumalai, and G. H. Lorimer (04-2006). Coarse-grained model of chaperonin-mediated protein folding. NHLBI Fellows Retreat, St. Michaels, Maryland.

G. Stan, D. Thirumalai, G. H. Lorimer, and B. R. Brooks (03-2006). Coarse-grained model of chaperonin-mediated protein folding. APS March Meeting, Baltimore, Maryland.

G. Stan, D. Thirumalai, and G. H. Lorimer, B. R. Broo (03-2006). Coarse-grained model of chaperonin-mediated protein folding. APS March Meeting, Baltimore, Maryland.

G. Stan, B. R. Brooks, D. Thirumalai, and G. H. Lorimer (05-2005). Computational studies of chaperonin-mediated protein folding. NHLBI Fellows Retreat, St. Michaels, Maryland.

G. Stan, B. R. Brooks, D. Thirumalai and G. H. Lorimer (04-2005). Identifying natural substrates for chaperonins using a sequence-based approach . Frontiers in Computational Biophysics symposium, National Institutes of Health, Bethesda, Maryland.

G. Stan, B. R. Brooks, D. Thirumalai, and G. H. Lorimer (03-2005). Computational studies of chaperonin-mediated protein folding. 229th American Chemical Society National Meeting, San Diego, California.

G. Stan, D. Thirumalai, G. H. Lorimer, and B. R. Brooks (02-2004). Annealing Action of the GroEL-GroES Chaperonin System. Biophysical Society Meeting, Baltimore, Maryland.

G. Stan (04-2003). Computational Studies of Chaperonin-mediated protein folding. Frontiers in Condensed Matter Theory symposium, The Pennsylvania State University, University Park, Pennsylvania.

P. Shrestha and G. Stan (10/10/2008). Substrate protein recognition mechanism of archaeal and eukaryotic chaperonins. Joint Meeting of the APS Ohio-Region Section, the AAPT Southern Ohio Section, and the ACS Dayton-Section , Dayton, OH.

Colloquia

G. Stan (06/12/2008). “Biological nanomachines at work: chaperonin-mediated protein folding. Dept. of Chemistry, Miami University.

G. Stan (11/03/2008). Secrets of biomolecular systems revealed by computer simulations: biological nanomachines for protein folding assistance. Dept. of Chemistry, Fisk University.

Lectures

G. Stan (08/21/2008). Biological nanomachines at work: chaperonin-mediated protein folding. Lambda Lunch Seminar Series, National Cancer Institute, National Institutes of Health.

Paper Presentations

G. Stan and M. Jayasinghe. Computational models of chaperonin-assisted protein folding. 235th American Chemical Society National Meeting, New Orleans. 04/09/2008.

M. Jayasinghe and G. Stan. Computational modeling of protein folding assistance by the eukaryotic chaperonin CCT. Joint Meeting of the APS Ohio-Region Section, the AAPT Southern Ohio Section, and the ACS Dayton-Section, Dayton, OH. 10/11/2008.

Events Organized

Zimmer scholar week (05/12/2008 to 05/16/2008), Dept. of Chemistry, University of Cincinnati.

Host of colloquium speaker Teresa Head-Gordon (11/21/2008), Dept. of Chemistry, University of Cincinnati.

Student Advising

Pooja Shrestha, , Supervisor, In Progress .

Blake Baird, , Supervisor, Completed .

Stefanie Young, Undergrad, Supervisor, Research, In Progress .

Kenneth Zampelli, Undergrad, Supervisor, Research, In Progress .

Dr. Manori Jayasinghe, , Supervisor, In Progress .

Service

Committee Member, Graduate Admissions, .

Committee Member, Theoretical Chemistry Committee, .

Courses Taught

15-CHEM-383 PHYSICAL CHEM III.

15-CHEM-721 ADV PHYS CHEM I .