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Assistant Professor
Chemistry - Tenure-Track Faculty
805 Crosley Tower
513-556-9200
suri.iyer@uc.edu
www.che.uc.edu/iyer

Professional Summary

In the Iyer group, we synthesize chemically defined glycans and study their biological functions. Specifically, we are interested in understanding how toxins and pathogens recognize specific carbohydrates to bind and infect cells. For example, botulinum toxins bind only to neuronal cells with high specificity and the seven serotypes differ in their binding and their potency. By developing a library of synthetic glycoconjugates and testing them with various strains, we expect to understand the factors that govern the recognition process. Knowledge gained from this research endeavor is expected to lead to the development of diagnostics and therapeutics for toxins, viruses and bacteria.

Research Support

(Co-PI) Tom Mantei, Suri S. Iyer, NUE: Integration of Nanoscale Science and Engineering into Undergraduate Curricula , National Science Foundation. (NSF 0532495); $ 200,000. Funded 03/01/2006 to 03/01/2008.

(Co-PI- ligand development) Alison A. Weiss, Suri S. Iyer, Glycoconjugate based diagnostics for bacterial toxins, NIH - NIAID. (U01); $ 1,206,954. Funded 08/01/2007 to 03/01/2011.

(co-PI) PI : Ian Papautsky. co - PI : Dionysios D. Dionysiou and Suri S. Iyer, A New Microfluidic Sensor for Nanoparticle Sizing and Separations, UC Institute of Nanoscience and Nanotechnology. 30000. Funded 01/01/2008 to 12/31/2009.

Peer Reviewed Publications

Iyer, S.S, Rele S. M., Chaikof, E. L. "Ring opening metathesis polymerization of hyaluronan disaccharide mimetics". Chem. Commun. (2003), 1518-1519.

Iyer, S.S., Rele S.M., Baskaran, S., Chaikof, E. L. "Design and synthesis of hyaluronan-mimetic gemini disaccharides". Tetrahedron 59 (2003), 6931-6938.

Rele S. M., Iyer, S.S., Chaikof, E. L. "Homodimerization of hyaluronan and heparan sulfate derivatives by olefin metathesis reaction". Tet. Lett. (2003), 44, 89-91.

Rele, S. M., Iyer, S. S., Baskaran, S., Chaikof, E. L. "Design and synthesis of dimeric heparinoid mimetics". J. Org. Chem. (2004), 69, 9159-9170.

Iyer, S. S., Anderson, A. S., Reed, S., Swanson B. I., Schmidt, J.G. "Synthesis of orthogonal functionalized oligoethylene glycols of defined lengths". Tet. Lett. (2004), 45, 4285-4288.

Weiss A. A., Iyer S. S. "Glycomics aims to interpret the third molecular language of cells". Microbe 2 (2007), 489-497.

Kale, R. R., Clancy, C. M., Vermillion, R. M., Johnson, E. A., Iyer, S. S. "Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin". A. Bioorg. Med. Chem. Lett. (2007), 17, 2459-2464.

Rele, S. M., Iyer S. S., Chaikof, E. L. "Hyaluronan-based glycoclusters as probes for chemical glycobiology". Tet. Lett. (2007), 48, 5055-5060.

Hatch, D. M., Weiss, A. A., Kale, R. R., Iyer, S. S. "Biotinylated bi- and tetra-antennary glycoconjugates for Escherichia coli detection". Chembiochem : a European journal of chemical biology (2008), 9, 2433-2442.

Kale, R. R., Mukundan, H., Price, D. N., Harris, J. F., Lewallen, D. M., Swanson, B. I., Schmidt, J. G., Iyer, S. S. "Detection of intact influenza viruses using biotinylated biantennary S-sialosides". Journal of the American Chemical Society (2008), 130, 8169-8171.

Kale, R. R., McGannon, C. M., Fuller-Schaefer, C., Hatch, D. M., Flagler, M. J., Gamage, S. D., Weiss, A. A., Iyer, S. S. "Differentiation between structurally homologous Shiga 1 and Shiga 2 toxins by using synthetic glycoconjugates". Angewandte Chemie (International ed.in English) (2008), 47, 1265-1268.

Kale, R. R., Clancy, C. M., Vermillion, R. M., Johnson, E. A., Iyer, S. S. "Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A". Bioorganic & medicinal chemistry letters (2007), 17, 2459-2464.

Iyer, S., Rele, S., Grasa, G., Nolan, S., Chaikof, E. L. "Synthesis of a hyaluronan neoglycopolymer by ring-opening metathesis polymerization". Chemical communications (Cambridge, England) (2003), (13), 1518-1519.

Publicity

American Chemical Society's Chemical and Engineering News. Fighting Food-borne Illness: Glycoconjugates that differentiate disease-causing toxins could be basis of simple assay., 2008. Journal: Angew. Chem. Int. Ed. Engl. 2008, 47,1265 -1268 Title : Differentiation between structurally homologous Shiga I and Shiga II toxins using synthetic glycoconjugates. This publicationw was highlighted in the Science and Technology Concentrates section of C&E News. (2008, 86, 42) " The bacterium Escherichia coli O157:H7 is notorious for causing food-borne illness. When it infects people, one would like to know as soon as possible which of two possible Shiga toxins the infect

July 9th ACS Presspac news release (www.acs.org/pressroom). http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=223&content_id=WPCP_010371&use_sec=true&sec_url_var=region1P41_1737, Web, 2008. Detecting flu viruses in remote areas of the world Journal: Journal of the American Chemical Society. 2008,130, 8169–8171Journal Article: “Detection of Intact Influenza Viruses using Biotinylated Biantennary S-Sialosides” The press release describes our research efforts on the detection of influenza virus. " Researchers in Ohio and New Mexico are reporting an advance in the quest for a fast, sensitive test to detect flu viruses — one that requires no refrigeration and can be u