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Paul S Horn
Professor
610C Old Chemistry Building
513-556-4069
paul.horn@uc.edu
http://math.uc.edu/~hornps
Professional Summary
EDUCATION
Ph.D.(Statistics), Princeton University, 1981.Advisor: John W. TukeyM.A.(Statistics), Princeton University, 1979.Sc.B.(Applied Mathematics), Brown University, 1977.
EXPERIENCE
Interim Assistant Head, Dept. of Mathematical Sciences, Univ. of Cincinnati, Sept. 2000 – Aug. 2001.
Visiting Research Professor, Departement de Mathematiques, Ecole Polytechnique Federale de Lausanne, Switzerland, July - September 1999.
Visiting Professor, Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, September – December 1999.
Full Professor, University of Cincinnati, 1993 - Present.
Scientist/Engineer, The Procter & Gamble Company, 1992 - 1994.
Associate Professor, University of Cincinnati, 1987 - 1993.
Assistant Professor, University of Cincinnati, 1983 - 1987.
Member of Technical Staff/Ph.D., Bell Laboratories, Holmdel, New Jersey, 1982 - 1983.
Visiting Assistant Professor, Department of Statistics and Actuarial Sci., University of Iowa, 1981 - 1982.
Research Assistant, Biostatistics Department, Mount Sinai School of Medicine, July - August, 1978.
Education
Ph.D., Princeton University, 1981.
Research Interests
Applied statistics and data analysis: robust methods, nonparametrics, quantile estimation, outlier resistance / detection, transformation / goodness-of-fit, regression – adaptive Least Trimmed Squares, methods for small samples. Applications to medicine, clinical chemistry, and the biological sciences
Research Support
Evaluation of Coenzyme Q10 Efficacy in Pediatric Patients With Down Syndrome, Lejeune Foundation. Funded 03/01/2006 to 02/29/2008.
Clinical Trials Network, Ohio Valley Node, National Institute of Drug Abuse. (2 U10 DA013732-06); Funded 09/01/2005 to 08/31/2011.
Mycardial Gene Delivery with Novel Polymeric Agents, National Institute of Health. (1R21 EB003938-01); Funded 07/01/2004 to 06/30/2006.
Evolution of HIV-1 env in HIV-1 Infected Individuals with and without HCV Co-infection, National Cancer Institute. (N01-CP-01004); Funded 06/01/2004 to 05/31/2005.
B-2 Microglobulin: Renal Biomarker of Workplace U Exposure, National Institute of Occupational Safety and Health. (1 R01 OH007976-001); Funded 09/30/2003 to 09/29/2005.
Induction of Bile Acid Synthesis in the Neonatal Liver, National Institute of Health. (HD39419); Funded 01/15/2002 to 12/31/2005.
Clinical Trials Network, Ohio Valley Node, National Institute of Drug Abuse. (1 U10 DA13732-01); Funded 10/01/2000 to 09/30/2005.
Hepatic C Viral Kinetics in Subjects Co-infected with HIV-I and HCV-I, Adult Aids Clinical Trial Group. (Q728-040-G413-1081); Funded 10/01/2000 to 12/31/2001.
Clinical Trials Operation, National Institute of Drug Abuse. (NO1DA-9-8095); Funded 06/01/2000 to 01/31/2001.
HCV Genomic Variability in HIV Infected Hemophiliacs, National Institute of Health. (5R01 AI49508-04); Funded 06/01/2000 to 05/31/2005.
Department of Health & Human Services Inter-Agency Agreement between the National Institute of Drug Abuse and the Veteran’s Administration. (IY01DA50038-00); Funded 10/01/1995 to 09/30/1997.
A Robust Approach to the Prediction Problem, National Science Foundation. (DMS-8706044); Funded 07-1987 to 12-1989.
Summer Faculty Research Fellowship, University of Cincinnati. Funded 1986
Taft Grant-in-Aid, University of Cincinnati. Funded 1984
Published Abstracts
Miles L, Tang PH, Bove KE, Horn PS, Morehart P, Wong B, deGrauw T, Miles MV (2007). Muscle Coenzyme Q10 Predicts Abnormal Mitochondrial Respiratory Chain Enzyme Activity in Children [Abstract]. Laboratory Investigation, 87, 313A.
Patterson BJ, Chalfonte-Evans M, Miles MV, Hickey F, Schapiro M, Horn P, Hotze S. (2006). Language impairment is associated with decreased plasma coenzyme Q10 levels in children with Down syndrome [Abstract]. Down Syndrome Quarterly, 8(1), 105.
M. Miles, J. Morrison, P. Tang, & A.J. Pesce (2004). Coenzyme Q10 Associations With Metabolic Syndrome [Abstract]. Clinical Chemistry, 50, A60.
T. Degrauw, M.V. Miles, J. Morrison, A.J. Pesce, & P.H. Tang (2003). Reference intervals for coenzyme Q10 in self-reported healthy adults [Abstract]. Clinical Chemistry, 49, A141-A142.
E.Eyster, J. Goedert, E.D. Keenan, M. Koziel, H. Qin, S.D. Rouster SD, & K.E. Sherman (2003). HCV RNA Quasispecies Evolution Associated with End Stage Liver Disease in a Longitudinal Cohort of HCV and HCV/HIV Infected Hemophilics [Abstract]. Gastroenterlolgy, 124(4), 251.
R.T. Chung, B. Israel, M.J. Koziel, M.G. Peters, S.D. Rouster, & K.E. Sherman (2003). Modeling HCV Viral Kinetic Response to PEG-IFN/Ribavirin in HCV/HIV Coinfected Patients [Abstract]. Hepatology, 38(4), 315.
M. Miles, P. Tang, L. Miles, P Steele, J. Bean, & T. DeGrauw (2001). Bioequivalence of Three Coenzyme Q10 Formulations in Healthy Adults [Abstract]. Journal of Clinical Pharmacology, 41, 1024.
Peer Reviewed Publications
Geracioti, T., Carpenter, L., Owens, M., Ekhator, N., Sanacora, G., Kinkea, B., Price, L., & Nemeroff, C. (2006). Elevated Cerebrospinal Fluid Substance P Concentrations in Post-traumatic Stress Disorder and Major Depression. The American Journal of Psychiatry, 163, 1-7.
Miles, M.V., Patterson, B.J., Schapiro, M.B., Hickey, F.J., Chalfonte-Evans, M., Horn, P.S., & Hotze, S. (2006). Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial. Pediatric Neurology, 35, 30-37.
Mazzella, F.M., Smith, D.S., Horn, P.S., Cotelingam, J.D., Rector, J.T., Shrit, M.A., Pesce, A.J., & Schumacher, H.R. (2006). Prognostic Significance of Pronormoblasts in Eryhtocyte Predominant Myelodysplastic Patients. The American Journal of Hematology, 81, 484-491.
Shire, N.J., Horn, P.S., Rouster, S.D., Dericks, S., Eyster, M.E., & Sherman, K.E. (2006). HCV Kinetics, Quasispecies, and Clearance in Treated HCV-Infected and HCV/HIV-1-Coinfected Hemophiliacs. Hepatology, 44, 1146 – 1157.
Winhusen, T., Somoza, E., Singal, B.M., Harrer, J., Apparaju, S., Mezinskis, J., Desai, P., Elkashef, A., Chiang, C.N., & Horn, P. (2006). Methylphenidate and Cocaine: A Placebo-Controlled Drug Interaction Study. Pharmacology Biochemistry and Behavior, 85, 29-38.
Baker, D.G., Ekhator, N.N., Kasckow, J.W., Dashevsky, B., Bednarik, L., & Geracioti, T.D. (2005). Higher Levels of Basal Serial CSF Cortisol in Combat Veterans With Posttraumatic Stress Disorder. The American. Journal of Psychiatry, 162, 992-994.
Miles, L., Miles, M.V., Tang, P.H., Quinlan, J.G., Wong, B., Wenisch, A., & Bovea, K.E. (2005). Ubiquinol: A Potential Biomarker for Tissue Energy Requirements and Oxidative Stress. Clinica Chimica Acta, 360, 87-96.
Sherman, K.E., Shire, N.J., Rouster, S.D., Peters, M.G., Koziel, M.J., & Chung, R.T. (2005). Viral Kinetic in Hepatitis C or Hepatitis C/Humin Immunodeficiency Virus-Infected Patients. Gastroenterology, 128, 313-327.
Miles, L., Miles, M.V., Tang, P.H., Wong, B., DeGrauw, T., Morehart, P.J., & Bovea, K.E. (2005). Muscle Coenzyme Q: A Potential Test for Mitochondrial Activity and Redox Status. Pediatric Neurology, 32, 318-324.
Wolfe, D.A. (2004). Extending Comtet's Decomposability of Integer Permutations. Pakistan Journal of Statistics, 20(1), 25-29.
Miles, M., Morrison, J., Tang, P., & Pesce, A.J. (2004). Coenzyme Q10 Changes Are Associated With Metabolic Syndrome. Clinica Chimica Acta, 344, 173-179.
Wolfe, D.A. (2004). A Rank-Based Goodness-of-Fit Approach to Testing for Non-Additivity in the Two-Way Layout with No Replications. Computational Statistics and Data Analysis, 46, 357-376.
Keenan, E.D., Rouster, S.D., Shire, N.J., & Sherman, K.E. (2004). Complexity and Diversity of Hepatitus C Virus RNA in African Americans and Whites: Analysis of the Envelope-Coding Domain. Journal of Infectious Diseases, 190, 511-514.
Miles, M.V., Tang, P.H., Morrison, J.A., Miles, L., DeGrauw, T., & Pesce, A.J. (2004). Age-related Changes in Plasma Coenzyme Q10 Concentrations and Redox State in Apparently Healthy Children and Adults. Clinica Chimica Acta, 347, 139-144.
Strawn, J.R., Ekhator, N.N., Baker, D.G., & Geracioti, T.D. (2004). Blood Pressure and Cerebrospinal Fluid Norepinephrine in Combat-Related Posttraumatic Stress Disorder. Psychosomatic Medicine, 66, 758-760.
Zucker, S.D., & Sherman, K.E. (2004). Serum Bilirubin Levels in the U.S. Population: An Analysis of the NHANES III Survey. Hepatology, 40, 827-835.
Winhusen, T.M., Somoza, E.G., Singal, B., Kim, K., & Rotrosen, J. (2003). Measuring Outcome in Cocaine Clinical Trials: A Comparison Of Sweat Patches with Urine Toxicology and Participant Self-Report. Addiction, 98, 317-324.
Degrauw, T., Miles, M.V., Morrison, J., Pesce, A.J., & Tang, P.H. (2003). Coenzyme Q10 Reference Intervals, but not Redox Status, are Affected by Gender and Race in Self-reported Healthy Adults. Clinica Chimica Acta, 332, 123-132.
Pesce, A.J. (2003). Reference Intervals: An Update. Clinica Chimica Acta, 334, 5-23.
Sherman, K.E., & Rouster, S.D. (2002). Comparison of Quantitative HCV RNA Methodologies in Patients Coinfected with Hepatitus C Virus and Human Immunodeficiency Virus. Clinical Infectious Diseases, 35, 482-487.
Miles, M.V., Tang, P.H., Miles, L., Steele, P., Bean, J., & DeGrauw, T. (2002). Single Dose Comparison of the Bioequivalence and Tolerability of Three Coenzyme Q10 Formulations in Healthy Adults. Nutrition Research, 22, 919-929.
Pesce, A. J. (2002). Effect of Ethnicity of Reference Intervals. Clinical Chemistry, 48, 1802-1804.
McConihay, J.A., & Woollett, L.A. (2001). The Effect of Maternal Hypercholesterolemia on Fetal Sterol Metabolism in the Golden Syrian Hamster. Journal of Lipid Research, 42, 1111-1119.
Feng, L., Li, Y.M., & Pesce, A.J. (2001). The Effect of Outliers and Non-healthy Individuals on Reference Interval Determination. Clinical Chemistry, 47, 2137-2145.
Pesce, A. J., & Copeland, B. (1999). Reference Interval Estimation Using Robust vs. Parametric and Nonparametric Analyses. Clinical Chemistry, 45(12), 2284-2285.
Lee, K.H., & Wolfe, D.A. (1999). A Rank-Based Contingency Table Approach to Testing for Equality of Treatment-Effect Patterns for Several Groups. Journal of Nonparametric Statistics, 11, 287-305.
Pesce, A.J., & Copeland, B. (1998). A Robust Approach to Reference Interval Estimation and Evaluation. Clinical Chemistry, 44(3), 622-631.
Fisher, A. (1994). Robust Prediction Intervals in a Regression Setting. Computational Statistics and Data Analysis, 17, 129-140.
Popenoe, D., Morriss III, S., & Norwood, K. (1994). Determination of Alkyl Sulfites and Alkyl Ethoxysulfates in Waste Water Treatment Plant Influents and Effluents and in River Water Using Liquid Chromatography/Ion-Spray Mass Spectrometry. Analytical Chemistry, 66(10), 1620-1629.
(1992). Quasi-Nonparametric Tolerance Regions Based on the Bootstrap. Communications in Statistics: Theory and Methods, 21(12), 3351-3367.
(1990). Robust Quantile Estimators for Skewed Populations. Biometrika, 77, 631-636.
(1989). On the Prediction of a Future M-Estimator. Communications in Statistics-Simulation, 18, 1155-1167.
(1988). On the Stochastic Ordering of Absolute Univariate Gaussian Random Variables. Annals of Statistics, 16, 1327-1329.
Britton, P.W., & Lewis, D.F. (1988). On the Prediction of a Single Future Observation from a Possibly Noisy Sample. The Statistician, 37, 165-172.
(1988). Some Results on Pooling. Statistics, 19, 9-14.
(1988). A Biweight Prediction Interval for Random Samples. Journal of the American StatisticalAssociation, 83, 249-256.
Schlipf, J.S. (1986). Who's Being Swindled?: A Case for Enlightened Naivete. Journal of Statistical Computation and Simulation, 26, 21-36.
Schlipf, J.S. (1986). On Generating Subsets of Order Statistics with Applications to Trimmed Means and Means of Trimmings. Journal of Statistical Computation and Simulation, 24, 83-97.
(1985). On Borrowing Spread from Auxiliary Samples in the One-Sample Problem. Communications in Statistics, A14(12), 3107-3124.
(1985). Back-to-Back Mixtures of Discrete Distributions. Journal of Statistical Planning and Inference, 11, 267-276.
(1983). Some Easy "t"-Statistics. Journal of the American Statistical Association, 78, 930-936.
Hogg, R.V., & Lenth, R.V. (1983). On Adaptive Estimation. Journal of Statistical Planning and Inference, 9, 333-343.
(1983). A Measure for Peakedness. The American Statistician, 37(1), 55-56.
(1982). The Finite Distribution of t-Statistics Based on Two Symmetric Order Statistics as a Sum of Orthant Probabilities. Biometrika, 69, 681-682.
(1981). Heteroscedasticity of Residuals: A Non-Parametric Alternative to the Goldfeld-Quandt Peak Test. Communications in Statistics, A10(8), 795-808.
Books
Pesce, Amadeo J. (2005). Reference Intervals: A User’s Guide. Washington, D.C.: AACC Press.
Book Chapters
Pesce, A.J. (2005). Statistics in the Pharmaceutical Industry, 3rd Edition. In C.R. Buncher and J.-Y. Tsay (Eds.), Chapter 24:Reference Intervals (Ranges): Distribution-Free Methods vs. Normal Theory Boca Raton, FL: CRC Press.
Encyclopedia Articles
Abdel H. El-Shaarawi & Walter W. Piegorsch (2002). Smoothing. In Encyclopedia of Environmetrics, Vol. 4, (pp. 2014-2020). Chichester: John Wiley and Sons.
Abdel H. El-Shaarawi & Walter W. Piegorsch (2002). Trimming and Winsorizing. In Encyclopedia of Environmetrics, Vol 4., (pp. 2264-2267). Chichester: John Wiley and Sons.
Norman L. Johnson & Samuel Kotz (1985). Pivot and Bi-pivot t-Statistics. In Encyclopedia of Statistical Sciences Volume 6, (pp. 750-751). New York: John Wiley and Sons.
Norman L. Johnson & Samuel Kotz (1985). Pivot Depth. In Encyclopedia of Statistical Sciences Volume 6, (pp. 751). New York: John Wiley and Sons.
Reviews
R.R. Wilcox (1998). Introduction to Robust Estimation and Hypothesis Testing. Technometrics, 77-78.
B.C. Arnold, N. Balakrishnan & H.I. Nagaraja (1993). A First Course in Order Statistics. SIAM Review, 525.
Technical Translations
D.A. Wolfe (1992). The Ohio State University: Department of Statistics.
(1982). Department of Statistics, Princeton University: Technical Report.
(1977). Brown University: Reports in Pattern Analysis.
Other Publications
Eyster, M.E., Sherman, K.E., & Shire, N.J. (2005). Viral Kinetic Parameters and Treatment Response in HIV/HCV Coinfected vs. HCV Infected Hemophiliacs. 12TH Conference on Retroviruses and Opportunistic Infections. Boston, MA.
Eyster, M.E., Sherman, K.E., & Shire, N.J. (2004). Viral Kinetic Modeling in HCV Monoinfected and HCV/HIV Coinfected Hemophiliacs Treated with Pegylated Interferon and Ribavirin. 11TH Conference on Retroviruses and Opportunistic Infections. San Francisco, CA.
Kafadar, K. (1996). An R2 for Robust Regression. The 1995 Proceedings of the Section on Quality and Productivity of the American Statistical Association 10-13.
Gilstein, C.Z. (1986). Centralized Inventory When Demand is Uncertain. Proceedings of the Business and Economics Statistics Section of the American Statistical Association 299-303.
Lectures
(02-2007). A Robust Approach to Reference Interval Determination. Department of Biostatistics, Medical College of Georgia.
(02-2007). A Robust Approach to Reference Interval Determination. Department of Mathematical Sciences, University of Colorado, Denver, CO.
(11-2006). Generating Subsets of Order Statistics. Ohio Statistical Conference, The Ohio State University.
(05-2006). Determination of Reference Intervals in Practice. Ohio River Valley Conference.
(04-2006). Robust Approaches to Reference Interval Determination. Department of Quantitative Health Sciences, The Cleveland Clinic Foundation.
(10-2005). Robust Approaches to Reference Interval Determination. Department of Biostatistics and Bioinformatics, University of Louisville.
(10-2004). Panel Discussion on Undergraduate Education in Statistics. Northern Kentucky University.
(06/29/2004). Some Thoughts on Reference Intervals. Biostatistics Journal Club, The Cincinnati Children’s Hospital Medical Center.
(04-2001). Testing for Non-Additivity in the Two-Way Layout with One Observation per Cell: A Rank-Based Approach. Department of Statistics & Actuarial Science, The University of Iowa, Iowa City, IA.
(02-2000). Robust Reference Intervals. Department of Toxicology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
(12-1999). A Rank-Based Goodness-of-Fit Approach to Testing for Non-Additivity in the Two-Way Layout with One Observation per Cell. Department of Mathematics, University of Colorado, Denver, Colorado.
(08-1999). A Rank-Based Goodness-of-Fit Approach to Testing for Non-Additivity in the Two-Way Layout with One Observation per Cell. Departement de Mathematiques, Ecole Polytechnique Federale de Lausanne, Switzerland.
(07-1997). Reference Interval Analysis Using: Parametric, Nonparametric, and Robust Approaches. Gordon Research Conference in Statistics in Chemistry & Chemical Engineering, Newport, RI.
(11-1996). A Rank-Based Goodness-of-Fit Approach to Testing for Non-Additivity in the Two-Way Layout with no Replications. Cincinnati Chapter of the American Statistical Association, Cincinnati, OH.
(09-1996). Essential Skills, Courses, and Experiences for the Statistician on the Job Market. Invited Panel Discussion, Twenty-Fourth Annual Mathematics and Statistics Conference, Oxford, Ohio.
(08-1996). Reference Interval Analysis Using: Parametric, Nonparametric, and Robust Approaches. Symposium on Statistics in the Sciences, Halifax, Nova Scotia.
(11-1995). Reference Intervals in Medicine: Parametric, Nonparametric, and Robust Methods. Twelfth Annual Ohio Statistics Conference: Synergy of Statistics and the Sciences, Battelle Auditorium, Columbus, OH.
(08-1995). An R2 for Robust Regression. Joint Statistical Meetings, Orlando, FL.
(06-1992). A Rank-Based Goodness-of-Fit Approach to Testing for Non-Additivity in the Two-Way Layout with no Replications. The Procter & Gamble Company, Cincinnati, OH.
(10-1991). Quasi-Nonparametric Tolerance Intervals Based on the Bootstrap. Dept. of Statistics, The Ohio State University, Columbus, OH.
(06-1991). A Semi-Nonparametric Tolerance Region Based on the Bootstrap. Eleventh International Symposium on Forecasting, New York City.
(05-1990). Robust Prediction for Skewed Distributions. the Department of Statistics, The Ohio State University, Columbus, OH.
(01-1990). Estimating Quantiles Robustly. Department of Decision Sciences and Engineering Systems, Rensselaer Polytechnic Institute, Troy, NY.
(08-1989). Robust Quantile Estimators for Skewed Populations. Joint Statistical Meetings, Washington, D.C..
(08-1988). On the Prediction of a Future M-Estimator. Joint Statistical Meetings, New Orleans, LA.
(10-1987). Robust Prediction Intervals. Dept. of Statistics and Actuarial Science, University of Iowa.
(07-1987). On the Prediction of a Single Future Observation from a Possibly Noisy Sample. The Institute of Statisticians, King's College, Cambridge University, Cambridge, England.
(06-1987). Collection and Analysis of Data for Decision Making. Institute of Advanced Manufacturing Sciences, Inc., Alumni Center, University of Cincinnati.
(08-1986). Centralized Inventory When Demand is Uncertain. Joint Statistical Meetings, Chicago, IL.
(08-1985). Variance Reduction in Light of CPU Time: Who’s Being Swindled?. Joint Statistical Meetings, Las Vegas, NV.
(08-1984). On Borrowing Spread from Auxiliary Samples. Joint Statistical Mtgs, Philadelphia, PA.
(01-1984). Pooling Denominators. Cincinnati Chapter of the American Statistical Association, Merrill Dow Pharmaceuticals.
(08-1983). Some Easy t-Statistics. Joint Statistical Meetings, Toronto, Canada.
(06-1983). On the Error Distribution of Special Services Forecasts. Symposium on Forecasting, Philadelphia, PA.
(03-1983). Modeling Demand for Special Services. Dept. of Statistics and Actuarial Science, University of Iowa.
(01-1983). Robust t-Statistics. Dept. of Management Science and Statistics, University of Maryland.
